| Identification | Back Directory | [Name]
DPI-3290 | [CAS]
182417-73-8 | [Synonyms]
DPI-3290
Org 41793
Benzamide, 3-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-hydroxyphenyl)methyl]-N-(3-fluorophenyl)-N-methyl- | [Molecular Formula]
C30H34FN3O2 | [MDL Number]
MFCD00937216 | [MOL File]
182417-73-8.mol | [Molecular Weight]
487.61 |
| Hazard Information | Back Directory | [Uses]
DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively. DPI-3290 is one of a series of novel centrally acting agents with potent antinociceptive activity[1]. | [in vivo]
DPI-3290 (Org 41793) (intravenous; 0.05 mg/kg) produces a 50% antinociceptive response in rats[1]. | [IC 50]
κ Opioid Receptor/KOR; δ Opioid Receptor/DOR | [References]
[1] Gengo PJ, et al. DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. J Pharmacol Exp Ther. 2003 Dec;307(3):1221-6. DOI:10.1124/jpet.103.054361 |
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MedChemExpress
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