| Chemical Properties | Back Directory | [form ]
Solid | [color ]
White to off-white | [Sequence]
RNA, (P-thio)((2'-O,4'-C-methylene)m5C-dA-(2'-O,4'-C-methylene)m5C-dG-dA- (2'-O,4'-C-methylene)m5U-(2'-O,4'-C-methylene)m5U-dA-(2'-O,4'-Cmethylene)G-dC-(2'-O,4'-C-methylene)A-(2'-O,4'-C-methylene)m5U-(2'-O,4'-Cmethylene)m5U-(2'-O,4'-C-methylene)A) |
| Hazard Information | Back Directory | [Uses]
Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma[1][2]. | [in vivo]
Cobomarsen (1 mg/kg; i.v. on days 0, 2, 4, and 7) inhibits tumor growth in mice carrying U2932 cells xenografts[2]. | Animal Model: | Five-to-six weeks old female NSG mice injected with U2932 cells | | Dosage: | 1 mg/kg | | Administration: | I.v. on days 0, 2, 4, and 7 | | Result: | Reduced tumor growth most significantly at day 7 and day 10.
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| [References]
[1] Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183(3):428-444. DOI:10.1111/bjh.15547
[2] Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27(4):1139-1149. DOI:10.1158/1078-0432.CCR-20-3139 |
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