| Identification | Back Directory | [Name]
Benzenamine, N-ethyl-4-pyrrolo[1,2-a]quinoxalin-4-yl- | [CAS]
1902146-75-1 | [Synonyms]
RI(dl)-2 TFA
Benzenamine, N-ethyl-4-pyrrolo[1,2-a]quinoxalin-4-yl- | [Molecular Formula]
C19H17N3 | [MOL File]
1902146-75-1.mol | [Molecular Weight]
287.36 |
| Chemical Properties | Back Directory | [Boiling point ]
460.2±45.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20mg/mL, clear | [form ]
Solid | [pka]
3.87±0.39(Predicted) | [color ]
Purple to purplish red |
| Hazard Information | Back Directory | [Biological Activity]
RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative th at selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 μM) without affecting its ssDNA-binding activity (IC50 >100 μM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC50 = 3.0 μM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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