| Identification | Back Directory | [Name]
Acetic acid, 2-[[2-[[(4,5-dichloro-1H-pyrrol-2-yl)carbonyl]amino]-6-benzothiazolyl]amino]-2-oxo- | [CAS]
1995132-67-6 | [Synonyms]
HSP90-IN-14
Acetic acid, 2-[[2-[[(4,5-dichloro-1H-pyrrol-2-yl)carbonyl]amino]-6-benzothiazolyl]amino]-2-oxo- | [Molecular Formula]
C14H8Cl2N4O4S | [MOL File]
1995132-67-6.mol | [Molecular Weight]
399.21 |
| Hazard Information | Back Directory | [Uses]
HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a Kd of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC50 values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively[1]. | [IC 50]
HSP90β: 0.26 ± 0.0 μM (Kd) | [References]
[1] Lamut A, et al. Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90. Bioorg Chem. 2020 May;98:103733. DOI:10.1016/j.bioorg.2020.103733 |
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