2070014-87-6

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2070014-87-6 Structure

Identification	Back Directory
[Name] MRT68921 HCl
[CAS] 2070014-87-6
[Synonyms] MRT68921 HCl,MRT-68921 HCl N-(3-((5-Cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide hydrochloride
[Molecular Formula] C25H35ClN6O
[MDL Number] MFCD30187515
[MOL File] 2070014-87-6.mol
[Molecular Weight] 471.05

Chemical Properties	Back Directory
[storage temp. ] under inert gas (nitrogen or Argon) at 2-8°C
[solubility ] DMSO: 5 mg/mL (11.51 mM);Ethanol: Insoluble
[Water Solubility ] Water: Insoluble

Hazard Information	Back Directory
[Uses] MRT68921 hydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.
[storage] Store at -20°C
[References] [1] Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83. DOI:10.1074/jbc.C114.627778

Spectrum Detail	Back Directory
[Spectrum Detail] MRT68921 HCl(2070014-87-6)¹HNMR

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