| Identification | Back Directory | [Name]
L-Prolinamide, N-[3-[2-(2-aminoethoxy)ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [CAS]
2138439-54-8 | [Synonyms]
VH032-C1-PEG2-NH2
L-Prolinamide, N-[3-[2-(2-aminoethoxy)ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [Molecular Formula]
C29H43N5O6S | [MOL File]
2138439-54-8.mol | [Molecular Weight]
589.75 |
| Chemical Properties | Back Directory | [Boiling point ]
867.6±65.0 °C(Predicted) | [density ]
1.235±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
methanol, ethyl acetate, DCM, THF, DMF, DMSO | [form ]
powder or crystals | [pka]
14.07±0.40(Predicted) | [color ]
off-white to light yellow | [Appearance]
beige powder |
| Hazard Information | Back Directory | [Description]
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
(S,R,S)-AHPC-C2-amine is a protein degrader building block for synthesizing molecules for targeted protein degradation and PROTAC technologies. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEG2-C2 crosslinker with an amine function group, which can be conjugated to other functionalized linkers and target protein ligands. |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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