| Chemical Properties | Back Directory | [Boiling point ]
543.522±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.322±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
4.068±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC50=0.437 nM, MCF-7 cells). Estrogen receptor modulator 8 inhibits MCF-7 cells proliferation with an IC50 value of 0.1 nM[1]. | [References]
[1] Guan D, et al. Preparation of 3-[4-(tetrahydro-1H-pyrrolo[3,4-b]indol-1-yl)phenyl]acrylic acid compound useful as estrogen receptor down-regulator (SERD). World Intellectual Property Organization, WO2018001232 A1. 2018-01-04. |
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