| Identification | Back Directory | [Name]
Benzonitrile, 2-[[7-[(3R)-3-amino-1-piperidinyl]-5-chloropyrazolo[1,5-a]pyrimidin-6-yl]methyl]- | [CAS]
2215027-46-4 | [Synonyms]
DPP-4-IN-1
Benzonitrile, 2-[[7-[(3R)-3-amino-1-piperidinyl]-5-chloropyrazolo[1,5-a]pyrimidin-6-yl]methyl]- | [Molecular Formula]
C19H19ClN6 | [MOL File]
2215027-46-4.mol | [Molecular Weight]
366.85 |
| Hazard Information | Back Directory | [Uses]
DPP-4-IN-1 (compound d1) is a potent DPP-4 (dipeptidyl peptidase 4) inhibitor, with an IC50of 49 nM. DPP-4-IN-1 is a structurally analogs of Alogliptin.html" class="link-product" target="_blank">Alogliptin (HY-A0023A). DPP-4-IN-1 can be used for diabetes research[1]. | [IC 50]
DPP-4: 49 nM (IC50) | [References]
[1] Shen J, et al. Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors. Eur J Med Chem. 2020 Dec 15;208:112850. DOI:10.1016/j.ejmech.2020.112850 |
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