| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, N-[4-[[3-[[2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetyl]amino]phenyl]methoxy]phenyl]-1-methyl- | [CAS]
2243151-81-5 | [Synonyms]
Sirt2-IN-6
1H-Pyrazole-4-carboxamide, N-[4-[[3-[[2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetyl]amino]phenyl]methoxy]phenyl]-1-methyl- | [Molecular Formula]
C26H26N6O3S | [MOL File]
2243151-81-5.mol | [Molecular Weight]
502.59 |
| Hazard Information | Back Directory | [Uses]
Sirt2-IN-6 (compound 24a) potent and selective inhibitor of SIRT2, with an IC50 of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer[1]. | [IC 50]
SIRT2: 0.815 μM (IC50) | [References]
[1] Yang LL, et, al. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem. 2018 Jul 15;155:806-823. DOI:10.1016/j.ejmech.2018.06.041 |
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