| Identification | Back Directory | [Name]
Pyrimidine, 2-methyl-4-(4-methyl-1-piperazinyl)-6-[[(2S)-2-(3-methyl-2-pyridinyl)-1-pyrrolidinyl]methyl]- | [CAS]
2304750-68-1 | [Synonyms]
CXCR4 antagonist 6
Pyrimidine, 2-methyl-4-(4-methyl-1-piperazinyl)-6-[[(2S)-2-(3-methyl-2-pyridinyl)-1-pyrrolidinyl]methyl]- | [Molecular Formula]
C21H30N6 | [MOL File]
2304750-68-1.mol | [Molecular Weight]
366.5 |
| Hazard Information | Back Directory | [Uses]
CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1]. | [IC 50]
CXCR4: 79 nM (IC50) | [References]
[1] Li Z, et al. Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity. Eur J Med Chem. 2020;205:112537. DOI:10.1016/j.ejmech.2020.112537 |
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