2365172-19-4

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2365172-19-4 Structure

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[Uses] XZ739, a Cereblon-dependent PROTAC BCL-XL (Bcl-2 family member) degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].
[IC 50] Bcl-xL: 2.5 nM (DC₅₀); Cereblon
[References] [1] Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186. DOI:10.1016/j.ejmech.2020.112186

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