| Identification | Back Directory | [Name]
1-Piperazinecarboxylic acid, 4-[[6-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-quinazolinyl]carbonyl]-2-methyl-, (2-methyl-1-oxopropoxy)methyl ester, (2R)- | [CAS]
2396529-58-9 | [Synonyms]
1-Piperazinecarboxylic acid, 4-[[6-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-quinazolinyl]carbonyl]-2-methyl-, (2-methyl-1-oxopropoxy)methyl ester, (2R)- | [Molecular Formula]
C26H30ClN7O5 | [MOL File]
2396529-58-9.mol | [Molecular Weight]
556.01 |
| Hazard Information | Back Directory | [Uses]
PAK4-IN-1 (Compound 19) is a potent, selective, orally active PAK4 inhibitor with robust anti-tumor efficacy in vivo. PAK4-IN-1 is stable under both acidic and neutral conditions[1]. | [IC 50]
PAK4 | [References]
[1] Jing Guo, et al. Synthesis, bioconversion, pharmacokinetic and pharmacodynamic evaluation of N-isopropyl-oxy-carbonyloxymethyl prodrugs of CZh-226, a potent and selective PAK4 inhibitor. Eur J Med Chem. 2020 Jan 15;186:111878. DOI:10.1016/j.ejmech.2019.111878 |
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