2434630-30-3

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2434630-30-3 Structure

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[Name] γ-Secretase modulator 11 hydrochloride
[CAS] 2434630-30-3
[Synonyms] γ-Secretase modulator 11 hydrochloride

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[Uses] γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 μM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease[1].
[References] [1] Sekioka R, et al. Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice. Bioorg Med Chem. 2020 Jun 1;28(11):115455. DOI:10.1016/j.bmc.2020.115455

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