| Identification | Back Directory | [Name]
Ethanol, 2-[[2-[4-[4-amino-5-(1H-indol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenoxy]ethyl]amino]- | [CAS]
2476764-11-9 | [Synonyms]
MPO-IN-5
Ethanol, 2-[[2-[4-[4-amino-5-(1H-indol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenoxy]ethyl]amino]- | [Molecular Formula]
C24H24N6O2 | [MOL File]
2476764-11-9.mol | [Molecular Weight]
428.49 |
| Hazard Information | Back Directory | [Uses]
MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M?1s?1[1]. | [References]
[1] Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020 Jun 15;28(12):115548. DOI:10.1016/j.bmc.2020.115548 |
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