| Identification | Back Directory | [Name]
5-Pyrimidinecarboxamide, 2-[2-[(6-bromo-1-methyl-1H-indol-3-yl)methyl]-2,6-diazaspiro[3.4]oct-6-yl]-N-hydroxy-, hydrochloride (1:1) | [CAS]
2482998-39-8 | [Synonyms]
HDAC1-IN-4
5-Pyrimidinecarboxamide, 2-[2-[(6-bromo-1-methyl-1H-indol-3-yl)methyl]-2,6-diazaspiro[3.4]oct-6-yl]-N-hydroxy-, hydrochloride (1:1) | [Molecular Formula]
C21H24BrClN6O2 | [MOL File]
2482998-39-8.mol | [Molecular Weight]
507.82 |
| Hazard Information | Back Directory | [Uses]
HDAC1-IN-4 (JX34) is a potent Plasmodium falciparum HDAC1 inhibitor shows antimalarial activity (IC50 < 5 nM) and lower cytotoxicity[1]. | [References]
[1] Wang M, et al. Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. J Med Chem. 2022;65(5):4156-4181. DOI:10.1021/acs.jmedchem.1c01993 |
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