| Identification | Back Directory | [Name]
1,4-Naphthalenedione, 2-(2-chloro-5-pyrimidinyl)- | [CAS]
2521629-86-5 | [Synonyms]
Anti-infective agent 3
1,4-Naphthalenedione, 2-(2-chloro-5-pyrimidinyl)- | [Molecular Formula]
C14H7ClN2O2 | [MOL File]
2521629-86-5.mol | [Molecular Weight]
270.67 |
| Hazard Information | Back Directory | [Uses]
Anti-infective agent 3 (compound 3l) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.47 and 0.13 μM, respectively. Anti-infective agent 3 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 4 μg/mL[1]. | [References]
[1] Kalt MM, et al. Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents. Eur J Med Chem. 2020 Dec 1;207:112837. DOI:10.1016/j.ejmech.2020.112837 |
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