2651196-69-7

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2651196-69-7 Structure

Identification	Back Directory
[Name] Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-
[CAS] 2651196-69-7
[Synonyms] CDK12-IN-4 Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-
[Molecular Formula] C20H20F2N8O
[MOL File] 2651196-69-7.mol
[Molecular Weight] 426.42

Hazard Information	Back Directory
[Uses] CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM). CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1].
[IC 50] CDK12: 0.641 μM (IC₅₀); CDK2/cyclinE: >20 μM (IC₅₀); CDK9/cyclinT1: >20 μM (IC₅₀)
[References] [1] Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

2651196-69-7 suppliers list

Company Name:	Shanghai Merlot Chemical Co., LTD
Tel:	15821661757
Website:	www.chemicalbook.com/ShowSupplierProductsList1059485/0_EN.htm

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