| Identification | Back Directory | [Name]
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2S,5R)-2,5-dimethyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[2-(1-methylethyl)-6-(methylsulfonyl)phenyl]- | [CAS]
2670380-74-0 | [Synonyms]
KRAS G12C inhibitor 45
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2S,5R)-2,5-dimethyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[2-(1-methylethyl)-6-(methylsulfonyl)phenyl]- | [Molecular Formula]
C32H33F2N5O5S | [MOL File]
2670380-74-0.mol | [Molecular Weight]
637.7 |
| Hazard Information | Back Directory | [Uses]
KRAS G12C inhibitor 45 (compound 78) is a potent KRAS G12C inhibitor[1]. | [IC 50]
KRas G12C | [References]
[1] LV Binhua, et al. Aryl or heteroaryl pyridone or pyrimidine derivative preparation method and use thereof. WO2021143693A1. |
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