| Identification | Back Directory | [Name]
Propanamide, N-[4-[[(aminoiminomethyl)amino]sulfonyl]phenyl]-3-mercapto- | [CAS]
2711044-25-4 | [Synonyms]
Metallo-β-lactamase-IN-4
Propanamide, N-[4-[[(aminoiminomethyl)amino]sulfonyl]phenyl]-3-mercapto- | [Molecular Formula]
C10H14N4O3S2 | [MOL File]
2711044-25-4.mol | [Molecular Weight]
302.37 |
| Hazard Information | Back Directory | [Uses]
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively[1]. | [References]
[1] Kaya C, et al. N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases. J Med Chem. 2022 Mar 10;65(5):3913-3922. DOI:10.1021/acs.jmedchem.1c01755 |
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