| Identification | Back Directory | [Name]
GSK737 | [CAS]
2748687-95-6 | [Synonyms]
GSK737
Benzamide, N-cyclopropyl-3-(1-methyl-1H-1,2,3-triazol-4-yl)-4-[(1S)-1-(2-pyridinyl)ethoxy]- | [Molecular Formula]
C20H21N5O2 | [MOL File]
2748687-95-6.mol | [Molecular Weight]
363.41 |
| Hazard Information | Back Directory | [Uses]
GSK737 is a BRD4 BD1 and BD2 inhibitor, with pIC50 values of 5.3 and 7.3 respectively. GSK737 has low clearance and good solubility and permeability in rat[1]. | [References]
[1] Aylott HE, et al. Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. J Med Chem. 2021 Mar 25;64(6):3249-3281. DOI:10.1021/acs.jmedchem.0c02156 |
|
|