| Identification | Back Directory | [Name]
4-(Phenylmethyl)-N-1H-pyrazolo[3,4-b]pyridin-3-yl-1-piperazinepropanamide | [CAS]
2761149-17-9 | [Synonyms]
4-(Phenylmethyl)-N-1H-pyrazolo[3,4-b]pyridin-3-yl-1-piperazinepropanamide | [Molecular Formula]
C20H24N6O | [MOL File]
2761149-17-9.mol | [Molecular Weight]
364.44 |
| Chemical Properties | Back Directory | [Boiling point ]
641.9±55.0 °C(Predicted) | [density ]
1.297±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
9.19±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
hAChE/Aβ1-42-IN-1 (Compound 16) is a potent inhibitor of hAChE and Aβ1-42 aggregation. hAChE/Aβ1-42-IN-1 shows acceptable relative safety upon hepG2 cell line and excellent BBB penetration with wide safety margin. hAChE/Aβ1-42-IN-1 has the potential for the research of Alzheimer disease (AD)[1]. | [IC 50]
AChE | [References]
[1] Waly OM, et al. Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents. Eur J Med Chem. 2022;231:114152. DOI:10.1016/j.ejmech.2022.114152 |
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