| Chemical Properties | Back Directory | [density ]
1.484±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
11.689±0.40(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter[1]. | [IC 50]
JAK2: 14 nM (DC50); JAK3: 11 nM (DC50); JAK2-fusion ALL: 24 nM (DC50); Cereblon | [References]
[1] Lisa J.Alcock,et al. Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.ACS Med.Chem.Lett.2022,13,3,475-482. |
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