| Chemical Properties | Back Directory | [Boiling point ]
718.2±60.0 °C(predicted) | [density ]
1.409±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
10.13±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
EZH2-IN-18 (compound 9e) is a potent inhibitor of enhancer of zeste homologue 2 (EZH2WT) , with the IC50 of 1.01 nM. EZH2-IN-18 shows inhibition in proliferation and induction in apoptosis in tumor cells[1]. | [References]
[1] Jin Cai, et al. Design, synthesis and activity evaluation of quinolinone derivatives as EZH2 inhibitors. Bioorg Med Chem Lett. 2024 Jun 1:105:129726. DOI:10.1016/j.bmcl.2024.129726 |
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