| Chemical Properties | Back Directory | [Boiling point ]
476.2±45.0 °C(Predicted) | [density ]
1.492±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
2.90±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Mtb-IN-2 (compound 10c) is an antimicrobial agent against Mycobacterium tuberculosis (Mtb), without cytotoxicity. Mtb-IN-2 significantly decreases colony-forming units (CFU) in spleen of murine tuberculosis models, and distinguishes both drug-sensitive and drug-resistant Mtb H37Rv strains. Mtb-IN-2 affects methionine metabolism but not folate pathway directly. | [References]
[1] Nawrot DE, et al. Antimycobacterial pyridine carboxamides: From design to in vivo activity. Eur J Med Chem. 2023 Oct 5;258:115617. DOI:10.1016/j.ejmech.2023.115617 |
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