| Identification | Back Directory | [Name]
PLpro inhibitor 19 | [CAS]
2863607-73-0 | [Synonyms]
PLpro inhibitor 19
1-Piperazinecarboxamide, N-[3-fluoro-5-[[[[1-[(1R)-1-(1-naphthalenyl)ethyl]-4-piperidinyl]carbonyl]amino]methyl]phenyl]-4-methyl- | [Molecular Formula]
C31H38FN5O2 | [MOL File]
2863607-73-0.mol | [Molecular Weight]
531.67 |
| Chemical Properties | Back Directory | [Boiling point ]
746.992±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.237±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
13.000±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
SARS-CoV-2-IN-106 (compound 19) is a SARS-CoV-2 papain-like protease inhibitor with the IC50 values of 0.44 μM and 0.18 μM for PLpro enzymatic and viral replication ,respectively[1]. | [References]
[1] Shan H, et al. Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol. 2021;28(6):855-865.e9. DOI:10.1016/j.chembiol.2021.04.020 |
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