| Chemical Properties | Back Directory | [Boiling point ]
790.2±60.0 °C(predicted) | [density ]
1.302±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
13.02±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
GK444 (Compound 15a) is a HDAC1/2 inhibitor (IC50: 100 and 92 nM for HDAC1/2 respectively). GK444 inhibits Caco-2 cells with IC50 of 4.1 μM. GK444 also reduces TGF-β1 induced COL1A1 mRNA levels in primary normal human lung fibroblasts. GK444 inhibits Bleomycin (HY-108345)-induced lung fibrosis in mice[1]. | [References]
[1] Gerokonstantis DT, et al. N-(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity. J Med Chem. 2023 Oct 26;66(20):14357-14376. DOI:10.1021/acs.jmedchem.3c01422 |
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