| Identification | Back Directory | [Name]
CAY10608 | [CAS]
457897-92-6 | [Synonyms]
CAY10608
CAY10608 Exclusive
N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide | [Molecular Formula]
C18H22Cl2N2O4S | [MDL Number]
MFCD18382110 | [MOL File]
457897-92-6.mol | [Molecular Weight]
433.35 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 12.5 mg/ml; DMSO: 14 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM).1 It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors.1 CAY10608 is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, CAY10608, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion.1 | [References]
1. Tahirovic, Y.A., Geballe, M., Gruszecka-Kowalik, E., et al. Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists J. Med. Chem. 51,5506-5521(2008). |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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