| Identification | Back Directory | [Name]
TP4 | [CAS]
551907-64-3 | [Synonyms]
Thiophene-4
Thiophene-4 >=98% (HPLC)
5-(Aminocarbonyl)-4-methyl-2-[(pentafluorobenzoyl)amino]-3-thiophenecarboxylic acid ethyl ester
3-Thiophenecarboxylic acid, 5-(aminocarbonyl)-4-methyl-2-[(2,3,4,5,6-pentafluorobenzoyl)amino]-, ethyl ester | [Molecular Formula]
C16H11F5N2O4S | [MDL Number]
MFCD01353700 | [MOL File]
551907-64-3.mol | [Molecular Weight]
422.33 |
| Hazard Information | Back Directory | [Biological Activity]
Thiophene-4 (TP4) is an inhibitor of polyketide synthase 13 (Pks13)which plays a critical role in the biosynthesis of mycolic acidan essential component of the cell wall in M. tuberculosisand is a potential new target for tuberculosis treatment. TP4 inhibits FadD32-dependent loading of the mycolic acid precursor meromycoloyl chain onto acyl carrier protein (ACP) domains located at the N terminus of Pks13preventing synthesis of mycolic acid and resulting in mycobacterial cell death. TP4 bacteriosidal activity is equivalent to treatment with the first-line drug isoniazidand enhances its activitybut is less likely to cause resistance. The minimal inhibitory concentration (MIC) values of TP4 against drug-susceptible multidrug-resistant M. tuberculosis strains is approximately 500 nM. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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