| Identification | Back Directory | [Name]
3(2H)-Quinazolinepropanamide, 1,4-dihydro-N-[(2-methoxyphenyl)methyl]-2,4-dioxo- | [CAS]
896356-25-5 | [Synonyms]
MMV665916
TLC3407-3786
3(2H)-Quinazolinepropanamide, 1,4-dihydro-N-[(2-methoxyphenyl)methyl]-2,4-dioxo- | [Molecular Formula]
C19H19N3O4 | [MOL File]
896356-25-5.mol | [Molecular Weight]
353.37 |
| Hazard Information | Back Directory | [Uses]
MMV665916, a quinazolinedione derivative, is an antimalarial agent. MMV665916 displays antiplasmodial activity against P. falciparum FcB1 strain with EC50 value of 0.4 μM and presents the high selectivity index (SI>250)[1]. | [IC 50]
Plasmodium | [References]
[1] Laura Mourot, et al. ?Structure-activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent. Bioorg Med Chem. 2021 Dec 1;51:116513. DOI:10.1016/j.bmc.2021.116513 |
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