1010731-97-1

中文名称 MLN 3897

英文名称 MLN 3897

CAS 1010731-97-1

分子式 C30H31ClN2O4

分子量 519.03

MOL 文件 1010731-97-1.mol

1010731-97-1 结构式

基本信息物理化学性质应用领域常见问题列表

基本信息

中文别名

化合物 T28072

英文别名

AVE9897
AVE-9897
MLN 3897
AVE 9897
[1]Benzoxepino[3,4-b]pyridine-7-carboxylic acid, 5-[3-[(4R)-5-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-1-piperidinyl]propylidene]-5,11-dihydro-

物理化学性质

沸点716.2±60.0 °C(Predicted)

密度1.304±0.06 g/cm3(Predicted)

酸度系数(pKa)4.16±0.20(Predicted)

应用领域

用途一

MLN-3897, also known as AVE-9897, is a C-C Motif Chemokine Receptor 1 (CCR1) antagonist potentially for the treatment of multiple sclerosis and rheumatoid arthritis. MLN3897 abrogates its effects by inhibiting Akt signaling. Moreover, MM cell-to-OC adhesion was abrogated by MLN3897, thereby inhibiting MM cell survival and proliferation. MLN3897 demonstrates significant impairment of OC formation (by 40%) and function (by 70%), associated with decreased precursor cell multinucleation and down-regulation of c-fos signaling.

常见问题列表

概述

CCR1 antagonist 10 (example 1) 是一种有效的具有口服活性的 CCR1 拮抗剂。CCR1 antagonist 10 抑制 125I-MIP-1α 与 THP-1 细胞膜的结合，Ki 值为 2.3 nM。