104869-26-3
104869-26-3 结构式
基本信息
8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/06/05 | HY-108672 | NF157 | 104869-26-3 | 1 mg | 2800元 |
| 2026/06/05 | HY-108672 | NF 157 NF157 | 104869-26-3 | 5 mg | 5600元 |
| 2026/06/05 | HY-108672 | NF 157 NF157 | 104869-26-3 | 10 mM * 1 mL in DMSO | 14164元 |
常见问题列表
pKi: 7.35 (P2Y11)
IC50: 463 nM (P2Y11), 1811 µM (P2Y1), 170 µM (P2Y2)
Ki: 44.3 nM (P2Y11), 187 µM (P2Y1), 28.9 µM (P2Y2)
NF157 displays selectivity for P2Y11 over P2Y1 (>650-fold), P2Y2 (>650-fold), P2X2 (3-fold), P2X3 (8-fold), P2X4 (>22-fold), and P2X7 (>67-fold) but no selectivity over P2X1.
NF157 (30 and 60 µM; 24 hours) causes a significant reduction in degradation of type II collagen in a dose-dependent manner. 60 µM NF157 nearly completely rescues type II collagen from degradation induced by TNF-α (10 ng/mL).
NF157 (30 and 60 µM; 24 hours) almost fully restores nuclear translocation of p65 triggered by TNF-α (10 ng/mL) and significantly reduces the luciferase activity of NF-κB.
Western Blot Analysis
| Cell Line: | SW1353 cells |
| Concentration: | 30 and 60 µM |
| Incubation Time: | 24 hours |
| Result: | Ameliorated TNF-α-induced degradation of type II collagen. |
Western Blot Analysis
| Cell Line: | SW1353 cells |
| Concentration: | 30 and 60 µM |
| Incubation Time: | 24 hours |
| Result: | Reduced TNF-α-induced activation of NF-κB. |