105737-62-0
中文名称
1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE
CAS
105737-62-0
分子式
C23H25F3N4O5.CH4O3S
分子量
590.57
MOL 文件
105737-62-0.mol
105737-62-0 结构式
基本信息
英文别名
CGP207122HClCGP 20712 mesylate
CGP 20712 DIHYDROCHLORIDE
CGP-20712A methanesulfonate salt
CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE
CGP-20712A methanesulfonate salt solid, >=98% (HPLC)
1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd
1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate
1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE
(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate
常见问题列表
生物活性
CGP 20712 A (CGP 20712 mesylate) 是一种高选择性 β1-adrenoceptor 拮抗剂,IC50 为 0.7 nM,是对 β2 肾上腺素受体的选择性约为 10,000 倍。靶点
IC50: 0.7 nM (β1-adrenoceptor)
体外研究
In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.
体内研究
Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.