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107015-83-8

中文名称 淀粉-Β-蛋白片段12-28
英文名称 H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
CAS 107015-83-8
分子式 C89H135N25O25
分子量 1955.18
MOL 文件 107015-83-8.mol
更新日期 2024/04/26 10:50:37
107015-83-8 结构式 107015-83-8 结构式

基本信息

中文别名
淀粉-Β-蛋白片段12-28
英文别名
SP17
VHHQKLVFFAEDVGSNK
β-Amyloid (12-28)
BETA-AMYLOID (12-28)
AMyloid b-Protein (12-28)
AMYLOID BETA-PROTEIN (12-28)
M.W. 1955.20 C89H135N25O25
AMYLOID, BETA- (12-28), HUMAN
Amyloidb-Peptide(12-28)(human)
AMYLOID B-PROTEIN FRAGMENT 12-28
所属类别
生物化工:多肽

物理化学性质

储存条件−20°C
溶解度≥195.5 mg/mL in DMSO; insoluble in EtOH; ≥59.8 mg/mL in H2O
形态固体
水溶解性Soluble to 0.70 mg/ml in water
序列H-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH

安全数据

WGK Germany3
淀粉-Β-蛋白片段12-28价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2023/03/20HY-P1051淀粉-Β-蛋白片段12-28
β-Amyloid (12-28)
107015-83-81mg800元
2023/03/20HY-P1051淀粉-Β-蛋白片段12-28
β-Amyloid (12-28)
107015-83-85mg2400元
2023/03/20HY-P1051淀粉-Β-蛋白片段12-28
β-Amyloid (12-28)
107015-83-810mg3800元

常见问题列表

生物活性
β-amyloid (12-28) 是 β-淀粉样蛋白 (β1-42) 的肽片段。 β1-42 是 42 个氨基酸的蛋白质,是老年斑核心的主要成分。β-amyloid (12-28) 具有聚集特性。β-amyloid (12-28) 有潜力用于阿尔茨海默氏病的研究。
靶点

Amyloid-β

体外研究

β-amyloid (12-28) may exert dysregulation cognitive effects by means of defective coordination of potassium channel function in nerve, glia and endothelial cells.
β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.

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