常见问题列表
NADPH oxidase 4 (NOX4); Reactive oxygen species (ROS)
Fulvene-5 (10 µM; 1 hour) facilitates the reversal of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures adaptive responses from pro-survival to radio-sensitization and vice versa. These changes are accompanied by corresponding reversals in the translocation of survivin to the nuclei of TP53 WT and to the cytoplasm of TP53 Mut cells. The potential role of NOX4 in the expression of the survivin-associated adaptive response is investigated by transfecting HCT116 cells with NOX4 siRNA oligomers to inhibit NOX4 expression. Under these conditions NOX4 expression is inhibited by about 50%.
Fulvene-5 (0.5-1.0 μM) treatment decreases the expression of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in a dose-dependent manner in bEnd.3 cells.
Fulvene-5 (120 mg/kg/d; intraperitoneal injection; daily; for 2 weeks; nude mice) treatment potently inhibits hemangioma growth in mice.
| Animal Model: | Nude mice injected with bEnd.3 cells |
| Dosage: | 120 mg/kg/d |
| Administration: | Intraperitoneal injection; daily; for 2 weeks |
| Result: | Tumor growth in mice was significantly reduced. |