1104662-66-9
中文名称
SNT-207858 free base
英文名称
SNT-207858 free base
CAS
1104662-66-9
分子式
C32H43Cl2N5O3
分子量
616.62
MOL 文件
1104662-66-9.mol
1104662-66-9 结构式
基本信息
中文别名
化合物 T12945 英文别名
SNT-207858 free base1-Pyrrolidinecarboxamide, N-[(1R)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-2-[4-[3-[(2R)-2-(1-pyrrolidinyl)butoxy]-2-pyridinyl]-1-piperidinyl]ethyl]-
物理化学性质
沸点813.0±65.0 °C(Predicted)
密度1.258±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 125 mg/mL (202.72 mM)
酸度系数(pKa)12.71±0.20(Predicted)
形态Solid
颜色White to off-white
SNT-207858 free base价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-11030A | SNT-207858 free base | 1104662-66-9 | 1 mg | 2045元 |
| 2025/05/22 | HY-11030A | SNT-207858 free base SNT-207858 free base | 1104662-66-9 | 5mg | 4500元 |
| 2025/05/22 | HY-11030A | SNT-207858 free base SNT-207858 free base | 1104662-66-9 | 10mM * 1mLin DMSO | 6100元 |
常见问题列表
生物活性
SNT-207858 free base 是一种选择性，能透过血脑屏障的，有口服活性的黑皮质素 (melanocortin; MC-4) 受体拮抗剂，SNT-207858 free base 抑制与 MC-4 受体结合，IC50 为 22 nM。SNT-207858 抑制 MC-4 活性，IC50 为 11 nM。靶点
MC-4 receptor
体外研究
SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5.
体内研究
SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice.
| Animal Model: | Mice with C26 adenocarcinoma-induced cachexia model |
| Dosage: | 30 mg/kg |
| Administration: | Oral administration; once daily; 15 days |
| Result: | Significantly reduced the tumor induced weight loss. |