1135242-13-5
中文名称
VU0357017
英文名称
VU 0357017 hydrochloride
CAS
1135242-13-5
分子式
C18H28ClN3O3
分子量
369.9
MOL 文件
1135242-13-5.mol
更新日期
2024/04/29 17:03:07
1135242-13-5 结构式
基本信息
中文别名
VU 0357017盐酸盐盐酸 VU 0357017
英文别名
CS-2319VU0357017
CID 25010775
SID 56353039
ML071 hydrochloride
VU 0357017 hydrochloride
VU0357017 monohydrochloride
Ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride
VU0-357017
VU 0357017
CID-25010775
VU-0357017 HYDROCHLORIDE
VU 0357017 HYDROCHLORIDE
4-[[2-[(2-Methylbenzoyl)aMino]ethyl]aMino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride
所属类别
生物化工：激动剂抑制剂VU0357017价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-19752A | VU0357017 VU0357017 hydrochloride | 1135242-13-5 | 5mg | 700元 |
| 2024/04/30 | HY-19752A | VU0357017 VU0357017 hydrochloride | 1135242-13-5 | 10mM * 1mLin DMSO | 770元 |
| 2024/04/30 | HY-19752A | VU0357017 VU0357017 hydrochloride | 1135242-13-5 | 10mg | 1200元 |
常见问题列表
生物活性
VU0357017 hydrochloride (CID-25010775)是一种强效的、中枢神经系统渗透性的高选择性 M1 激动剂，M1是 muscarinic acetylcholine receptors (mAChRs) 的一类亚型。VU0357017 hydrochloride 可在变构位点起作用以激活该受体，其EC50值为 477 nM 和 Ki值为 9.91 μM。靶点
| Target | Value |
|
M1 mAChR
(Cell-free assay) | 477 nM(EC50) |
|
M1 mAChR
(Cell-free assay) | 9.91 μM(Ki) |
体外研究
VU0357017 is selective for M
1
(K
i
=9.91 µM) over M
2
-M
5
mAChRs (K
i
=21.4, 55.3, 35.0, and 50.0 μM, respectively) in CHO cells.
VU0357017 (1 nM-100 μM) induces calcium release and ERK phosphorylation in a concentration-dependent manner in CHO cells.
体内研究
VU0357017 (1-10 mg/kg, i.p.) reverses scopolamine-induced disruption of the contextual fear conditioning response.
| Animal Model: | Male Sprague−Dawley rats (380-420 g) were pretreated with scopolamine |
| Dosage: | 1, 3, 10 mg/kg |
| Administration: | A single i.p. |
| Result: | Produced a significant reversal of the scopolamine-induced deficits at a dose of 10 mg/kg. |