1144113-16-5
1144113-16-5 结构式
基本信息
中文别名
八甘醇单三苯甲基醚 英文别名
Tr-PEG9Tr-PEG8-OH
2,5,8,11,14,17,20,23-Octaoxapentacosan-25-ol, 1,1,1-triphenyl-
2-(2-{2-[2-(2-{2-[2-(2-trityloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethanol
常见问题列表
生物活性
Tr-PEG8-OH 是一种不可降解 (non-cleavable) 的含 8 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。Tr-PEG8-OH是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。靶点
Non-cleavable
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PEGs
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体外研究
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.