1146-04-9
中文名称
隐陡头菌素M
英文名称
illudin M
CAS
1146-04-9
分子式
C15H20O3
分子量
248.32
MOL 文件
1146-04-9.mol
更新日期
2024/04/11 12:22:42
1146-04-9 结构式
基本信息
中文别名
隐陡头菌素M 英文别名
illudin M(3S)-2,3-Dihydro-3α,6β-dihydroxy-2,2,4,6-tetramethylspiro[5H-indene-5,1'-cyclopropan]-7(6H)-one
(3'S,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one
Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-, (3'S,6'R)-
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
熔点120-122.5° (Matsumoto); mp 128-130° (McMorris)
沸点452.4±45.0 °C(Predicted)
密度1.24±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
酸度系数(pKa)12.57±0.70(Predicted)
形态固体
常见问题列表
生物活性
Illudin M 是一种细胞毒性真菌倍半萜，可以从 Omphalotus olearius 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。体外研究
Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro.
Apoptosis Analysis
| Cell Line: | Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs) |
| Concentration: | 0.01 μM, 1 μM, 10 μM |
| Incubation Time: | 24 hours, 48 hours,72 hours, 96 hours, 120 hours |
| Result: | Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%). |