116783-35-8

中文名称 N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸

英文名称 FMOC-THR(GALNAC(AC)3-ALPHA-D)-OH

CAS 116783-35-8

分子式 C33H38N2O13

分子量 670.66

MOL 文件 116783-35-8.mol

更新日期 2024/04/16 09:23:25

116783-35-8 结构式

基本信息物理化学性质安全数据图谱信息 N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸价格(试剂级) 常见问题列表

基本信息

中文别名

半乳糖胺L-苏氨酸
芴甲氧羰基-苏氨酸(半乳糖胺(AC)3-Α-D)基
FMOC-THR[GALNAC(AC)3-伪-D]-OH
FMOC-L-THR(Α-D-GALNAC(AC)3)-OH游离态
N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-Α-D-吡喃半乳糖基)-L-苏氨酸
N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-Α-D-吡喃半乳糖基)-L-苏氨酸
N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸
N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸
N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-Α-D-吡喃半乳糖基)-L-苏氨酸,GALNAC L-THREONINE

英文别名

GalNAc-Thr
GALNAC L-THREONINE
FMOC-L-THR(TNAC4)-OH
Fmoc-Thr(Ac3GalNAcα)-OH
Fmoc-Thr(AcAcNH-α-Gal)-OH
FMoc-Thr-(Ac3AcNH-α-Gal)-OH
Fmoc-Thr(GalNAc(Ac)3-a-D)-OH
FMoc-Thr(α-D-GalNAc(Ac)3)-OH
FMOC-Thr(GalNAc(Ac)3-α-D)-OH
Fmoc-Thr[GalNAc(Ac)3-α-D]-OH

物理化学性质

熔点178-183°C

沸点857.1±65.0 °C(Predicted)

密度1.38±0.1 g/cm3(Predicted)

储存条件-20°C

酸度系数(pKa)3.32±0.10(Predicted)

旋光性 (optical activity)[α]22/D +55.0°, c = 1% in chloroform

InChIKeyOXLCJWGAUPPZQJ-ZNHCDWFHSA-N

安全数据

WGK Germany3

海关编码2932 99 00

图谱信息

N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸(116783-35-8)核磁图(¹HNMR)

N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/01/25	HY-P0232	N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH	116783-35-8	25mg	1900元
2024/01/25	HY-P0232	N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH	116783-35-8	50mg	3040元
2024/01/25	HY-P0232	N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH	116783-35-8	100mg	4860元

常见问题列表

生物活性

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是用于研究制备癌症疫苗的结构单元。

体外研究

The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome.