1173900-37-2
中文名称
AZD6482(s)
英文名称
AZD6482(s)
CAS
1173900-37-2
分子式
C22H24N4O4
分子量
408.45
MOL 文件
1173900-37-2.mol
更新日期
2024/06/10 01:28:25
1173900-37-2 结构式
基本信息
中文别名
化合物 T30261 英文别名
AZD6482(s)AZD6482 (S-isomer)
AZD6482 (S-ISOMER)
AZD6482 (S)
AZD6482
AZD-6482
AZD 6482.
2-((S)-1-(7-Methyl-2-morpholino-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid
应用领域
用途一
AZD6482 (S-isomer), CAS#1173900-37-2, is an isomer of AZD6482 (MedKoo Cat#406268) with S-configuration. AZD6482 is a potent, selective and ATP competitive PI3Kβ inhibitor (IC(50) 0.01 μm). AZD6482 inhibited insulin-induced human adipocyte glucose uptake in vitro (IC(50) of 4.4 μm). This is the first human target validation for PI3Kβ inhibition as anti-platelet therapy showing a mild and generalized antiplatelet effect attenuating but not completely inhibiting multiple signaling pathways with an impressive separation towards primary hemostasis. AZD6482 at 'supratherapeutic' plasma concentrations may attenuate insulin signaling, most likely through PI3Kα inhibition.