118908-07-9

中文名称化合物 EICAR

英文名称 5-ethynyl-1-ribofuranosylimidazole-4-carboxamide

CAS 118908-07-9

分子式 C11H13N3O5

分子量 267.24

MOL 文件 118908-07-9.mol

118908-07-9 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 EICAR

英文别名

5-ethynyl-1-ribofuranosylimidazole-4-carboxamide
1H-Imidazole-4-carboxamide, 5-ethynyl-1-β-D-ribofuranosyl-

物理化学性质

熔点182-185 °C

沸点686.311±55.00 °C(Press: 760.00 Torr)(predicted)

密度1.673±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

酸度系数(pKa)13.240±0.70(predicted)

应用领域

用途一

EICAR is a drug which acts as an inhibitor of the enzyme IMP dehydrogenase. It is a nucleoside derivative which has both anti-cancer and antiviral effects, and was originally developed for the treatment of leukemia, but was unsuccessful in human clinical trials. It has broad spectrum antiviral effects with activity against vaccinia virus, Semliki forest virus, Junin virus, reovirus, influenza, measles virus and respiratory syncytial virus among others, although it is not active against SARS. This useful spectrum of activity means that EICAR and related derivatives continue to be investigated for the treatment of viral diseases.