1191911-26-8
中文名称
CZC25146
英文名称
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
CAS
1191911-26-8
分子式
C22H25FN6O4S
分子量
488.54
MOL 文件
1191911-26-8.mol
更新日期
2025/04/30 11:36:04
1191911-26-8 结构式
基本信息
中文别名
CZC-25146游离态N-(2-((5-氟-2-((2-甲氧基-4-吗啉基苯基)氨基)嘧啶-4-基)氨基)苯基)甲磺酰胺
英文别名
CZC-25146CHEMBL2397014
LRRK2 Inhibitor II
LRRK2 INHIBITOR II
CZC25146
CZC 25146
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
N-(2-((5-fluoro-2-((2-methoxy-4- morpholinophenyl)amino)pyrimidin- 4- yl)amino)phenyl)methanesulfonamide
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
CZC-25146/N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
Methanesulfonamide, N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点697.4±65.0 °C(Predicted)
密度1.436±0.06 g/cm3(Predicted)
储存条件Inert atmosphere,2-8°C
储存条件under inert gas (nitrogen or Argon) at 2-8°C
溶解度≥24.45 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
酸度系数(pKa)8.48±0.10(Predicted)
形态固体
颜色Pale purple to purple
应用领域
用途1
CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons鈥檚 disease, and is ATP-competitive.