1192810-88-0
中文名称
化合物 T26862
英文名称
(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE
CAS
1192810-88-0
分子式
C18H20N4O
分子量
308.39
MOL 文件
1192810-88-0.mol
1192810-88-0 结构式
基本信息
中文别名
化合物 T26862 英文别名
(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE应用领域
用途一
BMS-902483 is a potent α7 partial agonist, which improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm. Preclinical and early clinical data suggest that α7 nicotinic acetylcholine receptor (nAChR) agonists have potential for the treatment of cognitive and negative symptoms in schizophrenia patients