1197196-63-6
中文名称
MS0124
英文名称
MS0124
CAS
1197196-63-6
分子式
C20H29N5O3
分子量
387.48
MOL 文件
1197196-63-6.mol
更新日期
2025/11/19 11:21:16
1197196-63-6 结构式
物理化学性质
沸点582.6±60.0 °C(Predicted)
密度1.232±0.06 g/cm3(Predicted)
酸度系数(pKa)8.84±0.70(Predicted)
形态Solid
颜色White to off-white
应用领域
用途一
MS0124 is a Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. MS0124 was 34-fold more selective for GLP (IC50 =_x000D_
13 ± 4 nM) over G9a (IC50 = 440 ± 63 nM). G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates