1202073-26-4

中文名称 3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]Methyl]-

英文名称 3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]Methyl]-

CAS 1202073-26-4

分子式 C26H22FN3O2S

分子量 459.54

MOL 文件 1202073-26-4.mol

1202073-26-4 结构式

基本信息应用领域

基本信息

中文别名

化合物 T29971

英文别名

AMG 369
KB74649
KB-74649
KB 74649
KCMALGDZUKTGJR-UHFFFAOYSA-N
3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]Methyl]-

应用领域

用途一

AMG-369, also known as KB74649, is a potent dual S1P1/S1P5 agonist with limited activity at S1P3 and no activity at S1P2/S1P4. Dosed orally at 0.1 mg/kg, AMG-369 is shown to reduce blood lymphocyte counts 24 h postdose and delay the onset and reduce the severity of experimental autoimmune encephalomyelitis in rat.