1210004-12-8
中文名称
4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
英文名称
JZL 195
CAS
1210004-12-8
分子式
C24H23N3O5
分子量
433.46
MOL 文件
1210004-12-8.mol
更新日期
2025/05/12 11:38:16
1210004-12-8 结构式
基本信息
中文别名
4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯 英文别名
CS-1586JZL 195
JZL-195
JZL 195
JZL195
4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点581.8±50.0 °C(Predicted)
密度1.303±0.06 g/cm3(Predicted)
储存条件Sealed in dry,Store in freezer, under -20°C
溶解度加热时在DMSO中的溶解度≥5mg/mL
酸度系数(pKa)6.13±0.10(Predicted)
形态粉末
颜色白色至米色
4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-15250 | 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯 JZL195 | 1210004-12-8 | 10 mM * 1 mLin DMSO | 477元 |
| 2025/02/08 | HY-15250 | 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯 JZL195 | 1210004-12-8 | 5mg | 500元 |
| 2025/02/08 | HY-15250 | 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯 JZL195 | 1210004-12-8 | 10mg | 820元 |
常见问题列表
生物活性
JZL195是有效的FAAH和MAGL抑制剂，IC50分别为2 nM和4 nM。靶点
| Target | Value |
|
FAAH
() | 2 nM |
|
MAGL
() | 4 nM |
体外研究
JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC
50
values of 13 and 19 nM, respectively).
JZL195 inhibits rat and human FAAH and MAGL enzymes with IC
50
values in the range of ≈10-100 nM based on competitive ABPP assays.
体内研究
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay.
| Animal Model: | Male C57BL/6J mice |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone. |