1252802-38-2

中文名称化合物 T28179

英文名称 NMK-TD 100

CAS 1252802-38-2

分子式 C19H17N3O3S

分子量 367.42

MOL 文件 1252802-38-2.mol

1252802-38-2 结构式

基本信息应用领域常见问题列表

基本信息

中文别名

化合物 T28179

英文别名

NMK-TD100
NMK-TD-100
NMK-TD 100

应用领域

用途一

NMK-TD-100 is a novel microtubule modulating agent. NMK-TD-100 blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin. Polymerization of tissue purified tubulin into microtubules was inhibited by NMK-TD-100 with an IC50 value of 17.5±0.35 μM. The binding of NMK-TD-100 to tubulin was estimated to be ~10 times faster than that of colchicine. NMK-TD-100 exerted anti-proliferative activity by disrupting microtubule functions through tubulin binding and provided insights into its potential of being a chemotherapeutic agent.

常见问题列表

概述

NMK-TD-100 是微管 (microtubule) 调节剂。NMK-TD-100 与微管蛋白结合，抑制微管蛋白聚合 (IC50 为 17.5 µM)，抑制有丝分裂，降低线粒体膜电位 (MMP)。NMK-TD-100 抑制 HeLa 细胞增殖 (IC50 为 1.42 µM)，将细胞周期停滞在 G2/M 期，诱导 HeLa 细胞凋亡 (apoptosis)。