1278553-16-4

中文名称化合物 T24933

英文名称 Methanone, cyclohexyl[4-(5-isoquinolinylsulfonyl)-1-piperazinyl]-

CAS 1278553-16-4

分子式 C20H25N3O3S

分子量 387.5

MOL 文件 1278553-16-4.mol

1278553-16-4 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 T24933

英文别名

VCC234718
VCC-234718
VCC 234718
Methanone, cyclohexyl[4-(5-isoquinolinylsulfonyl)-1-piperazinyl]-

物理化学性质

沸点627.2±65.0 °C(Predicted)

密度1.304±0.06 g/cm3(Predicted)

酸度系数(pKa)4.32±0.13(Predicted)

应用领域

用途一

VCC234718 is a IMPDH inhibitor.VCC234718 showed growth inhibitory activity against Mycobacterium tuberculosis (Mtb). VCC234718 was identified by phenotypic screening of a 15344-compound library. VCC234718 inhibits Mtb GuaB2 with a Ki of 100 nM and is uncompetitive with respect to IMP and NAD+. VCC234718 inhibits Mtb GuaB2 with a Ki of 100 nM and is uncompetitive with respect to IMP and NAD+.