1281870-42-5

中文名称 1281870-42-5

英文名称 Rhosin (hydrochloride)

CAS 1281870-42-5

更新日期 2025/10/27 11:52:23

分子式 C20H19ClN6O

分子量 394.86

MOL 文件 1281870-42-5.mol

1281870-42-5 结构式

基本信息物理化学性质图谱信息 1281870-42-5价格(试剂级) 常见问题列表

基本信息

中文别名

RHO抑制剂(RHOSIN盐酸盐)

英文别名

Rhosin HCl
G04 HYDROCHLORIDE
Rhosin (hydrochloride)
D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
(R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride

物理化学性质

储存条件-20°C储存

溶解度DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol

形态固体

颜色Light yellow to yellow

图谱信息

1281870-42-5(1281870-42-5)核磁图(¹HNMR)

1281870-42-5价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/09/19	S8988	1281870-42-5 Rhosin hydrochloride	1281870-42-5	5mg	3470元
2025/09/19	S8988	Rhosin hydrochloride	1281870-42-5	10mM (1mL in DMSO)	4070.43元
2025/09/19	S8988	1281870-42-5 Rhosin hydrochloride	1281870-42-5	25mg	7770元

常见问题列表

生物活性

Rhosin (G04) hydrochloride (HCl) 是RhoA亚家族 Rho GTPases 的强效特异性抑制剂，Kd值约为0.4 uM。Rhosin hydrochloride 可诱导细胞凋亡。

靶点

Target	Value
Rho (Cell-free assay)	0.4 μM(Kd)

体外研究

Rhosin hydrochloride dose-dependently reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres with an EC ₅₀ ~30-50 μM, and causes decreased size and reduced number of mammospheres in MCF7 cells.

体内研究

Rhosin (40 mg/kg; i.p.) treatment prevents social avoidance caused by social defeat stress. Rhosin also blocks sucrose preference deficits induced by defeat in C57Bl6/J (Jackson) mice.
Rhosin (30 µM; bilateral, intra- Nucleus Accumbens (NAc) infusions) attenuates stress-induced social avoidance. Rhosin blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs). Rhosin prevents decreased excitatory transmission on NAc D1-MSNs. Rhosin enhances spine density in defeat mice.

Animal Model:	D1-GFP or D2-GFP hemizygote mice on a C57BL/6J background
Dosage:	40 mg/kg
Administration:	I.p.
Result:	Rhosin was systemically administered 15 min prior to defeat to block RhoA activation. While defeat significantly reduced the time that experimental mice spent interacting with a novel mouse, Rhosin administration suppressed this effect without affecting locomotor behaviors.