1284150-65-7
中文名称
AZELIRAGON DIHYDROCHLORIDE
英文名称
Azeliragon HCl
CAS
1284150-65-7
分子式
C32H39Cl2N3O2
分子量
568.58
MOL 文件
1284150-65-7.mol
1284150-65-7 结构式
基本信息
中文别名
化合物 T2507L2 英文别名
TTP488 HClAzeliragon HCl
Azeliragon HCl (TTP488
Azeliragon hydrochloride
Azeliragon dihydrochloride
应用领域
用途一
Azeliragon, also known as TTP488 and PF-04494700, is a potent and orally active RAGE inhibitor. RAGE (receptor for advanced glycation endproducts) is a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain. In preclinical studies, azeliragon decreased brain amyloid in mice and improved their performance on behavior tests. Azeliragon is a promising agent for for Alzheimer's disease and cerebral amyloid angiopathy.